A Novel Reductive Transformation of Oxazepam to Nordiazepam Observed During Enzymatic Hydrolysis
نویسندگان
چکیده
منابع مشابه
A novel reductive transformation of oxazepam to nordiazepam observed during enzymatic hydrolysis.
beta-Glucuronidase is an enzyme often employed to de-conjugate beta-glucuronides during urinary drug testing for benzodiazepines. It is commonly accepted that use of beta-glucuronidase is a preferred method of hydrolysis over acid-catalyzed hydrolysis, which is known to induce benzodiazepine degradation and transformation. Literature to date, however, has not reported any cases of benzodiazepin...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 2010
ISSN: 0146-4760,1945-2403
DOI: 10.1093/jat/34.5.243